Protein Info for MMP_RS05235 in Methanococcus maripaludis S2

Annotation: exodeoxyribonuclease III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 249 TIGR00633: exodeoxyribonuclease III (xth)" amino acids 1 to 248 (248 residues), 327.5 bits, see alignment E=5.9e-102 TIGR00195: exodeoxyribonuclease III" amino acids 1 to 248 (248 residues), 315.9 bits, see alignment E=2.2e-98 PF03372: Exo_endo_phos" amino acids 4 to 241 (238 residues), 114.1 bits, see alignment E=4.2e-37

Best Hits

Swiss-Prot: 57% identical to EXOA_BACSU: Exodeoxyribonuclease (exoA) from Bacillus subtilis (strain 168)

KEGG orthology group: K01142, exodeoxyribonuclease III [EC: 3.1.11.2] (inferred from 100% identity to mmp:MMP1012)

Predicted SEED Role

"Exodeoxyribonuclease III (EC 3.1.11.2)" in subsystem DNA repair, bacterial (EC 3.1.11.2)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.11.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYH9 at UniProt or InterPro

Protein Sequence (249 amino acids)

>MMP_RS05235 exodeoxyribonuclease III (Methanococcus maripaludis S2)
MKMLSWNVNGIRACLKNGFMNFLERESPDIMCIQETKVQSGQVQLGLDGYFQYWNYAERK
GYSGTAIFTKIKPNNVILGMENSEHNNEGRVITLEFDEYYLVNVYTPNSQRGLTRLEYRQ
KWDEDFLSYIKTLETKKPVVFCGDLNVAHKEIDLKNPKTNVKNAGFTPEERNGFDNIVNS
GFLDTFREFNNEPDNYSWWSYRFNARARNIGWRIDYFCISKSLRNNLKDAYIMPEVMGSD
HCPVGIIFE