Protein Info for MMP_RS05215 in Methanococcus maripaludis S2
Annotation: indole-3-glycerol phosphate synthase TrpC
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 69% identical to TRPC_PYRAB: Indole-3-glycerol phosphate synthase (trpC) from Pyrococcus abyssi (strain GE5 / Orsay)
KEGG orthology group: K01609, indole-3-glycerol phosphate synthase [EC: 4.1.1.48] (inferred from 100% identity to mmp:MMP1008)MetaCyc: 65% identical to indole-3-glycerol phosphate synthase (Thermococcus kodakarensis)
Indole-3-glycerol-phosphate synthase. [EC: 4.1.1.48]
Predicted SEED Role
"Indole-3-glycerol phosphate synthase (EC 4.1.1.48)" in subsystem Tryptophan synthesis (EC 4.1.1.48)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (17/18 steps found)
- superpathway of L-tryptophan biosynthesis (12/13 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
- superpathway of chorismate metabolism (25/59 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.48
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LYI3 at UniProt or InterPro
Protein Sequence (229 amino acids)
>MMP_RS05215 indole-3-glycerol phosphate synthase TrpC (Methanococcus maripaludis S2) MTINFKKQANAIKNFDKNPIIAEIKVHSPKYGDLLKGRSEMDILRIYEEAGAVGISYITD KQHFNGNFDMFKKICENTELPVLRKDFLTTKDEIEKTASAGASTVLIIARLLKENTAEFV DFALECGLDTLVEVHNTEEIEIAKSTNTTMIGINNRDISKLELDDGTVSLTENLADLIPK DRILVSESGIANLTDLKTALKYADAALIGTSFMTAENQNEFVKSFVEGK