Protein Info for MMP_RS05060 in Methanococcus maripaludis S2

Annotation: AAA family ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 260 PF02374: ArsA_ATPase" amino acids 3 to 53 (51 residues), 32.2 bits, see alignment 1.7e-11 PF01656: CbiA" amino acids 4 to 235 (232 residues), 81.5 bits, see alignment E=1.3e-26 PF13614: AAA_31" amino acids 5 to 181 (177 residues), 40.7 bits, see alignment E=6.3e-14

Best Hits

Swiss-Prot: 51% identical to Y823_METJA: Uncharacterized ATP-binding protein MJ0823 (MJ0823) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07321, CO dehydrogenase maturation factor (inferred from 100% identity to mmp:MMP0977)

MetaCyc: 45% identical to CooC (Rhodospirillum rubrum)
RXN-12291

Predicted SEED Role

"CO dehydrogenase accessory protein CooC (nickel insertion)" in subsystem Carbon monoxide induced hydrogenase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYL4 at UniProt or InterPro

Protein Sequence (260 amino acids)

>MMP_RS05060 AAA family ATPase (Methanococcus maripaludis S2)
MKIAITGKGGVGKTTFSGTLACILSEKYKVYAIDADPDMNLASSLGITEKITPISKMKDL
IKERTCAEQGSSFGEVFKINPKTSDLPEKLSVNYDKNGNLKIMVMGTVEKGGTGCVCPAS
VLLKALIRNLILKKDEVVILDMEAGIEHLGRKTAEAVDVMIIVSEASSKSMETVERIKKL
AEEIGIKKIVCVLNKISNETEKSFAKENLNRIGLEILGCIPYDSEVSVADMKREPLVLYE
NSKAKNAIKEISEKIMNLKN