Protein Info for MMP_RS04900 in Methanococcus maripaludis S2

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 613 PF02730: AFOR_N" amino acids 23 to 201 (179 residues), 71.4 bits, see alignment E=9e-24 PF01314: AFOR_C" amino acids 236 to 518 (283 residues), 69.9 bits, see alignment E=2.2e-23

Best Hits

Swiss-Prot: 57% identical to Y1185_METJA: Uncharacterized protein MJ1185 (MJ1185) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K11389, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) [EC: 1.2.7.6] (inferred from 100% identity to mmp:MMP0945)

Predicted SEED Role

"Glyceraldehyde-3-phosphate: ferredoxin oxidoreductase (EC 1.2.7.6)" in subsystem Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 1.2.7.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.7.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYP3 at UniProt or InterPro

Protein Sequence (613 amino acids)

>MMP_RS04900 hypothetical protein (Methanococcus maripaludis S2)
MNILIDGSRQNYEELEESEFPISFGINLHTKQETWKYDAFDEKNLFCFGKGILPIIGGHR
LIFSFRSPLWDGFHFSAMGGAGYTFKDTGIQNVAITGKCEVPTVIVLNGEEDKLKIEFMP
FTEEITDIYEFNDKIIDLFKEKNYRAFLVGPASKTTNMGGIYSQTIRNGKIVEGSEDWAA
RGGGGSVLYQAHNVLGVVFFGKKTPEKNLKEIVEEHYNKPYTKVVLEHTEKYRYSEEKKT
GGTFGNNYHVTMELTPVFNWRMPFIDKNKRMKLHKKIIEYFVNRFDEEAIETKNWTNCGE
PCPVVCKKYRKGLHVDYEPYEANGPCIGVFDIYAADKVVHTIDKLGFDAIEFGNLCSWTF
ELLDNGMLKPEEVGIEKPVFDISNFENDEDILKNSMHNAEQAVKLAEIIAFQTNEFGKIC
KSGTRRAGKILNEKYPDRIKDKKFEDFGVYDSFGERGQISPTMYWAIGNFMPYLIQGKYL
THYQCGVFLEPEELAELSVKNSIEEITLENLGICRFHRKWVTPIIEKLVKEMSDVNLNEE
SMELFKKIAKYDSNIGCPEMESERVKELIIAGAFEFENEKWSKEFENGNFDEYIKRVLEK
YSELLEIDWKLKE