Protein Info for MMP_RS04855 in Methanococcus maripaludis S2

Annotation: shikimate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00507: shikimate dehydrogenase
  • amino acids 7 to 278 (272 residues), 324.4 bits, E=2.3e-101
• PF08501: Shikimate_dh_N
  • amino acids 11 to 93 (83 residues), 106.3 bits, E=1.2e-34
• PF01488: Shikimate_DH
  • amino acids 116 to 194 (79 residues), 33.4 bits, E=6.8e-12
• PF18317: SDH_C
  • amino acids 245 to 273 (29 residues), 47.1 bits, see alignment (E = 2.4e-16)

Best Hits

Swiss-Prot: 100% identical to AROE_METMP: Shikimate dehydrogenase (NADP(+)) (aroE) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 100% identity to mmp:MMP0936)

MetaCyc: 65% identical to shikimate dehydrogenase monomer (Methanocaldococcus jannaschii)
Shikimate dehydrogenase. [EC: 1.1.1.25]

Predicted SEED Role

"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (17/18 steps found)
• chorismate biosynthesis II (archaea) (12/12 steps found)
• superpathway of L-tryptophan biosynthesis (12/13 steps found)
• superpathway of L-phenylalanine biosynthesis (9/10 steps found)
• superpathway of L-tyrosine biosynthesis (9/10 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis I (6/7 steps found)
• superpathway of chorismate metabolism (25/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.25

Sequence Analysis Tools

See Q6LYQ2 at UniProt or InterPro

Protein Sequence (278 amino acids)

>MMP_RS04855 shikimate dehydrogenase (Methanococcus maripaludis S2)
LINSKTKLVGLIGHPVDHSFSPIMHNAAIKDLKINYRYFAFDVSEENLKDVVAGAKAFNF
RGFNITIPHKMNIMKYLDEIDCDAEAIGAVNTVKIENGKAIGYNTDGIGVKKALEEKTGI
LINKNILIIGSGGASRAVSFELAKDNNLTIVNRNIEKAENLSKEISRKLKKENPLNYGGL
DINIENFDIIINTTPVGMYPHTEVEPVIPLNNIKKDAVVMDLIYNPLEPVFLKEAKKYGA
KTINGIGMLVYQGAVSFEIWTGIKPDIFVMKKSIISKI