Protein Info for MMP_RS04795 in Methanococcus maripaludis S2

Annotation: tRNA (pseudouridine(54)-N(1))-methyltransferase TrmY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 PF04013: Methyltrn_RNA_2" amino acids 2 to 199 (198 residues), 223 bits, see alignment E=1.6e-70

Best Hits

Swiss-Prot: 100% identical to TRMY_METMP: tRNA (pseudouridine(54)-N(1))-methyltransferase (trmY) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0924)

Predicted SEED Role

"protein of unknown function DUF358"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYR4 at UniProt or InterPro

Protein Sequence (200 amino acids)

>MMP_RS04795 tRNA (pseudouridine(54)-N(1))-methyltransferase TrmY (Methanococcus maripaludis S2)
LKEFIIKANKAVTNGEINLKDLPGSSGRLDLLCRCVNSAFFLSHDMRRDTIFYSVNYGSP
NPPVALKFVGSELKRVSPDERSIALFIKKALEKDASELWKESTSGIYSSKREFRDIILEK
KNEGKRIFYLHLNGKPLEDFEFKNQDDEDFLFVLGDHIGIGDEDEEFLEEIGAEKISLSP
LELHADHCIILVHNILDRLK