Protein Info for MMP_RS04570 in Methanococcus maripaludis S2

Annotation: serine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to SYS2_METMP: Type-2 serine--tRNA ligase (serS) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01875, seryl-tRNA synthetase [EC: 6.1.1.11] (inferred from 100% identity to mmp:MMP0879)

MetaCyc: 100% identical to seryl-tRNA synthetase subunit (Methanococcus maripaludis)
Serine--tRNA ligase. [EC: 6.1.1.11]; 6.1.1.11 [EC: 6.1.1.11]

Predicted SEED Role

"Seryl-tRNA synthetase (EC 6.1.1.11), archaeal" (EC 6.1.1.11)

MetaCyc Pathways

tRNA charging (19/21 steps found)
L-selenocysteine biosynthesis II (archaea and eukaryotes) (4/4 steps found)
L-selenocysteine biosynthesis I (bacteria) (3/3 steps found)
shinorine biosynthesis (3/8 steps found)
vanchrobactin biosynthesis (2/8 steps found)
enterobactin biosynthesis (1/11 steps found)
superpathway of chorismate metabolism (25/59 steps found)
colibactin biosynthesis (6/38 steps found)

KEGG Metabolic Maps

Aminoacyl-tRNA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See O30520 at UniProt or InterPro

Protein Sequence (514 amino acids)

>MMP_RS04570 serine--tRNA ligase (Methanococcus maripaludis S2)
MRFELEGRIIFSKDVSEETQKDIIEVLENGDIFLKGVPEGKENEASKIEGYEFEGKDLKL
NMTSGTYTRAHEGIVRLKKPIMEKVGRKHQIGIRDVAIDTYVVTITATPSKVAELKGLKV
PECEVELDNEKIKILFKNLGDGELKRNIIDRAIKFVKTELDKQEQDLTFEVCKIAPGTIV
SDYKATREITFDKDPTELAEPYGWVKRFPGRGQWFYTAPMAKLFRAFESLIVEECIEKVG
FDECLFPKLIPLDVMYKMRYLEGLPEGMYYVCPPKREPEMFRDFVNEMMIKKEIPIDKLK
TLLRDPGYVLAPAQCEPFYTFFDHELVDVDSPSKFFDKSGWTYRWEGGGAKGLDRVNEFL
RGECVWMGSPEFVEKVRDDTLKYAEKLAEKLDLEYWTEVGDDPFYLEGRKNEDRGIEFPD
VPKYEMRLWLPHVKDERKGVAVTSANIHGTHFVEGFGIKDYKDRKVWTGCTGYGLSRWLI
GFLAQYGYNYEDWPEIIQKKVGKLPEIPKLITWP