Protein Info for MMP_RS04540 in Methanococcus maripaludis S2

Annotation: tetratricopeptide repeat protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 567 PF13181: TPR_8" amino acids 139 to 169 (31 residues), 27.5 bits, see alignment (E = 1.5e-09) amino acids 415 to 440 (26 residues), 17.8 bits, see alignment (E = 2.1e-06) amino acids 443 to 474 (32 residues), 14.9 bits, see alignment (E = 1.7e-05) amino acids 477 to 509 (33 residues), 27 bits, see alignment (E = 2.2e-09) PF07719: TPR_2" amino acids 141 to 169 (29 residues), 29.5 bits, see alignment (E = 3.6e-10) amino acids 477 to 509 (33 residues), 28.9 bits, see alignment (E = 5.3e-10) PF00515: TPR_1" amino acids 141 to 170 (30 residues), 35.2 bits, see alignment (E = 5.2e-12) amino acids 477 to 509 (33 residues), 36.9 bits, see alignment (E = 1.5e-12) PF13374: TPR_10" amino acids 142 to 166 (25 residues), 15.8 bits, see alignment (E = 8.2e-06) amino acids 478 to 505 (28 residues), 24.5 bits, see alignment (E = 1.5e-08) PF13414: TPR_11" amino acids 144 to 176 (33 residues), 31.8 bits, see alignment (E = 6.6e-11) PF13432: TPR_16" amino acids 414 to 475 (62 residues), 24.8 bits, see alignment E=1.8e-08 amino acids 449 to 508 (60 residues), 25.1 bits, see alignment 1.4e-08 amino acids 486 to 537 (52 residues), 25.6 bits, see alignment 9.8e-09 PF10373: EST1_DNA_bind" amino acids 431 to 526 (96 residues), 26.1 bits, see alignment E=4.4e-09 PF13431: TPR_17" amino acids 431 to 462 (32 residues), 22.7 bits, see alignment (E = 5.8e-08) amino acids 465 to 497 (33 residues), 25.6 bits, see alignment (E = 6.8e-09) amino acids 498 to 530 (33 residues), 25.5 bits, see alignment (E = 7.5e-09) PF13424: TPR_12" amino acids 477 to 541 (65 residues), 37.6 bits, see alignment E=1.4e-12 PF13176: TPR_7" amino acids 478 to 508 (31 residues), 16.5 bits, see alignment (E = 5e-06) PF14559: TPR_19" amino acids 487 to 547 (61 residues), 38.7 bits, see alignment E=7.2e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0873)

Predicted SEED Role

"TPR domain protein, putative component of TonB system" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYW2 at UniProt or InterPro

Protein Sequence (567 amino acids)

>MMP_RS04540 tetratricopeptide repeat protein (Methanococcus maripaludis S2)
MADYNNAVVFYDTSGIEYSKQIKKTLERGFERECFLINLDNRENTLSRLNLAMKTSKYVI
FLFSSMYSNENMLDEAKTAFNSDKHIISLKLDDPELKKQISIHQSEFEDNYGLSKKVNDE
VEKLKKMEKKGTDFVESQISFNMGNIYFNFGKYAEAIRCYKKAVKIIPDFVDALHNFNSL
SNMNLFDMGEEPKKPVLYKDVTIDELVPDIFSNTVQKEPEEPQKYSELEPEELEDLILDG
EIGENLEEIGSEDELTEKIDDKLPEIDESKDKSKAQPEDELNETFEEGIEYETFEVIDAE
EKNEISDENLEISSLEPEFEEKSIFKLEKETEQPELEENLEPVLEVPEELVEDVEILDAS
EEDIEKELENQEVIIEEKLETLDELLDKSELESELVEEHTYEIDNNEFLEILSFANTLYE
SGDFEAAKTEYKKAIALNPGNSEVHNHYGCLLEYLEKYGEAEIEFKKAVALDGSNSKAYN
NLATFLAKSEKYDEAEEHYKKAIEIAPDYWAAIYNLAAMYAALKRYDEAVAQVKSMVKIF
RSDGNIKEVLELKKLIKHLKKLKIQKS