Protein Info for MMP_RS04320 in Methanococcus maripaludis S2
Annotation: uroporphyrinogen decarboxylase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 100% identity to mmp:MMP0830)Predicted SEED Role
"Methylcobalamin methyltransferase MMP0830"
MetaCyc Pathways
- superpathway of heme b biosynthesis from glutamate (7/10 steps found)
- superpathway of heme b biosynthesis from glycine (4/8 steps found)
- heme b biosynthesis I (aerobic) (1/4 steps found)
- heme b biosynthesis II (oxygen-independent) (1/4 steps found)
- heme b biosynthesis V (aerobic) (1/4 steps found)
- heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
- superpathway of heme b biosynthesis from uroporphyrinogen-III (1/6 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (1/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (1/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (1/9 steps found)
- superpathway of bacteriochlorophyll a biosynthesis (4/26 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.37
Use Curated BLAST to search for 4.1.1.37
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LYZ9 at UniProt or InterPro
Protein Sequence (363 amino acids)
>MMP_RS04320 uroporphyrinogen decarboxylase family protein (Methanococcus maripaludis S2) MDYPDKMTPAQRAAAKAKGEPADRVACNPNIANGMARIAGYKISQFNDDPEALADAIIKT YRRFGADGARIFTDLFLVSEAMGAKVRKPEDNTADLEEPAINDMSEFDKLKVIDPYTQGR IPVHLRAIEIVRDEIASEVGVTASVVGPFTNAFFLIGVEKMTKMLLKDPESVHKLCEISL QSCIALTDAVLEKGVGVTISEPLSSCTVVSPKHFREFSAPYLKRLIDHIKARTGKLVIHI CGITDPIWDDLVEMGVDVLSIDNVADMEKCAETVGDKMVIAGNVDPSAIMYAGSREDVRK ATIKCAKQGLKAKKGFMIMSGCSLPVEVPIENIDAMMDTAREMGWPVTEEKLDYLLSFDK YKD