Protein Info for MMP_RS03745 in Methanococcus maripaludis S2
Annotation: phenylacetate--CoA ligase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to PAAK_THET2: Phenylacetate-coenzyme A ligase (TT_C0602) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
KEGG orthology group: K01912, phenylacetate-CoA ligase [EC: 6.2.1.30] (inferred from 100% identity to mmp:MMP0715)Predicted SEED Role
"Phenylacetate-coenzyme A ligase (EC 6.2.1.30)" in subsystem Aromatic amino acid interconversions with aryl acids (EC 6.2.1.30)
MetaCyc Pathways
- penicillin G and penicillin V biosynthesis (1/4 steps found)
- phenylacetate degradation II (anaerobic) (1/4 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (2/9 steps found)
- phenylacetate degradation I (aerobic) (1/9 steps found)
- superpathway of phenylethylamine degradation (1/11 steps found)
- anaerobic aromatic compound degradation (Thauera aromatica) (2/27 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.2.1.30
Use Curated BLAST to search for 6.2.1.30
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LZB4 at UniProt or InterPro
Protein Sequence (432 amino acids)
>MMP_RS03745 phenylacetate--CoA ligase (Methanococcus maripaludis S2) MIWNETIECMDREEMRELQSKRLSDTVSRVYHNVPFYRKKMQSMGVYPEDIESIDDISKL PFTTKQDLRDNYPFGIFSVPMGEIVRVHASSGTTGKPTVVGYTRRDIAMWSEIVARALSC AGASRDDFIQIAYGYGLFTGGLGLHYGGEKLGATVIPISGGNTQKQIQLMADFKTTVLAC TPSYALYLAETLEDSGMTADDINLRVGIFGAEPWTPSMRKEIENKLGIKAMDIYGLSEVM GPGVACDCEYQEGLHINEDHFVPEIIDPVTLKPLPAGSEGELVFTTITKEGMPLLRYRTR DLTSLNYEKCKCGRTLVRMNKCTGRSDDMLIIRGVNVFPSQIESVLLEMSETKPHYLLIV DRINNLDVLEVWVEIEDQFFSDKISMFEQLSKKIKHKIESTLGISVKIKLVEPKTIERSE GKSKRVIDKRKL