Protein Info for MMP_RS03600 in Methanococcus maripaludis S2

Annotation: triose-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00121: TIM
  • amino acids 5 to 215 (211 residues), 148.8 bits, E=2.1e-47
• TIGR00419: triose-phosphate isomerase
  • amino acids 5 to 208 (204 residues), 236.5 bits, E=1.7e-74

Best Hits

Swiss-Prot: 75% identical to TPIS_METJA: Triosephosphate isomerase (tpiA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01803, triosephosphate isomerase (TIM) [EC: 5.3.1.1] (inferred from 99% identity to mmx:MmarC6_0200)

MetaCyc: 75% identical to triosephosphate isomerase monomer (Methanocaldococcus jannaschii)
Triose-phosphate isomerase. [EC: 5.3.1.1]; 4.2.3.- [EC: 5.3.1.1]

Predicted SEED Role

"Triosephosphate isomerase (EC 5.3.1.1)" in subsystem Calvin-Benson cycle or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes or MLST (EC 5.3.1.1)

MetaCyc Pathways

• chorismate biosynthesis II (archaea) (12/12 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (16/18 steps found)
• glycolysis V (Pyrococcus) (10/10 steps found)
• 3-dehydroquinate biosynthesis II (archaea) (7/7 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
• glycolysis II (from fructose 6-phosphate) (9/11 steps found)
• glycolysis IV (8/10 steps found)
• Calvin-Benson-Bassham cycle (10/13 steps found)
• gluconeogenesis I (10/13 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• lactate biosynthesis (archaea) (4/5 steps found)
• gluconeogenesis III (9/12 steps found)
• glycolysis III (from glucose) (8/11 steps found)
• homolactic fermentation (8/12 steps found)
• superpathway of anaerobic sucrose degradation (13/19 steps found)
• glycolysis VI (from fructose) (7/11 steps found)
• sucrose degradation V (sucrose α-glucosidase) (2/5 steps found)
• oxygenic photosynthesis (10/17 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (10/17 steps found)
• superpathway of hexitol degradation (bacteria) (10/18 steps found)
• glycerol degradation to butanol (8/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (10/19 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (12/22 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (14/26 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (35/56 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (14/27 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (13/26 steps found)
• superpathway of N-acetylneuraminate degradation (10/22 steps found)
• ethene biosynthesis V (engineered) (12/25 steps found)

KEGG Metabolic Maps

• Carbon fixation in photosynthetic organisms
• Fructose and mannose metabolism
• Glycolysis / Gluconeogenesis
• Inositol phosphate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.1

Protein Sequence (221 amino acids)

>MMP_RS03600 triose-phosphate isomerase (Methanococcus maripaludis S2)
IKPNVIINYKTYTESVGKSGLAIAKAAEKVSEESGVTIGVAPQFLDLRMILDEVNIPVYA
QHMDAVTPGSSTGHILPDALKDAGVTGTLLNHSERRMLLADLEKCIEISNKLGLKTVVCT
NNIPVSKAVSALNPTSIAVEPPELIGSGIPVSKANPEVVSGTVREVREINKNVEILCGAG
ISKGEDVKSALELGTNGVLLASGVVKAKNVEDAIRELIAEI