Protein Info for MMP_RS03095 in Methanococcus maripaludis S2

Annotation: diphthine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00522: diphthine synthase
  • amino acids 1 to 254 (254 residues), 376.9 bits, E=2.3e-117
• PF00590: TP_methylase
  • amino acids 1 to 220 (220 residues), 62.3 bits, E=3.1e-21

Best Hits

Swiss-Prot: 100% identical to DPHB_METMP: Diphthine synthase (dphB) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00586, diphthine synthase [EC: 2.1.1.98] (inferred from 100% identity to mmp:MMP0588)

MetaCyc: 51% identical to diphthine synthase monomer (Pyrococcus horikoshii)
Diphthine synthase. [EC: 2.1.1.98]

Predicted SEED Role

"Diphthine synthase (EC 2.1.1.98)" (EC 2.1.1.98)

MetaCyc Pathways

• diphthamide biosynthesis I (archaea) (1/3 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.98

Sequence Analysis Tools

See Q6LZN6 at UniProt or InterPro

Protein Sequence (255 amino acids)

>MMP_RS03095 diphthine synthase (Methanococcus maripaludis S2)
MLVMAGLGLYDERDVTLKTLDFAKKVDKIYAEFYTAILTGTTMEKIEGTLQKPITVLDRE
KVEYETNKLIDEAKDKDIMFLTAGDPMVATTHVDIAVEARKKGIEVVIINAPSIYSAIGI
TGLQLYKFGKTTSIVFPEPNYFPETPYDVIKDNLKLGYHTLCLLDIQADKERFMTANEGL
DALLKIEEKRKENVISEETEVAVVARAGSINPGLYYGKIKDLLNYDFKSPLHCVIIPGKL
HFMEEDALKYLFENI