Protein Info for MMP_RS03035 in Methanococcus maripaludis S2
Annotation: 4-hydroxy-tetrahydrodipicolinate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to DAPA_METMP: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Methanococcus maripaludis (strain S2 / LL)
KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 100% identity to mmp:MMP0576)MetaCyc: 44% identical to 4-hydroxy-tetrahydrodipicolinate synthase (Bacillus subtilis)
DIHYDRODIPICSYN-RXN [EC: 4.3.3.7]
Predicted SEED Role
"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (14/15 steps found)
- L-lysine biosynthesis VI (7/7 steps found)
- L-lysine biosynthesis I (8/9 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
- L-lysine biosynthesis III (6/7 steps found)
- dipicolinate biosynthesis (3/4 steps found)
- aspartate superpathway (18/25 steps found)
- L-lysine biosynthesis II (6/9 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.2.1.52 or 4.3.3.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LZP8 at UniProt or InterPro
Protein Sequence (289 amino acids)
>MMP_RS03035 4-hydroxy-tetrahydrodipicolinate synthase (Methanococcus maripaludis S2) MQGVYPAIITPLKENKVDYDGLRNNIDFLIENGVSGVIPVGTTGESPTLTPLEHEKVVEK VVEFVDGRVEVIAGTGSNSTSEALEFSQYAEDVGVDGVLLITPYYNKPTQEGLKRHFGEI ANSINVPIVLYNVPSRTALNIEPETIKYLFNEYSNISAVKEANPNLSQVSEVLDSCDIDI LSGNDELTLPIISLGGKGVVSVIANIAPKEFVQMVDFANAGKFDKAKEIHYKLFPLMKLM FVETNPIPIKTAMNMLGMPSGELRLPLCEMAESNKLKLQNALNNLGLLK