Protein Info for MMP_RS03015 in Methanococcus maripaludis S2

Annotation: GTP 3' 8-cyclase MoaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 297 TIGR02668: probable molybdenum cofactor biosynthesis protein A" amino acids 1 to 296 (296 residues), 418.4 bits, see alignment E=6.8e-130 PF04055: Radical_SAM" amino acids 15 to 157 (143 residues), 115 bits, see alignment E=6.5e-37 PF13353: Fer4_12" amino acids 19 to 117 (99 residues), 33.6 bits, see alignment E=6.9e-12 PF06463: Mob_synth_C" amino acids 179 to 293 (115 residues), 70.4 bits, see alignment E=2.1e-23

Best Hits

Swiss-Prot: 100% identical to MOAA_METMP: Probable GTP 3',8-cyclase (moaA) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K03639, molybdenum cofactor biosynthesis protein (inferred from 100% identity to mmp:MMP0571)

Predicted SEED Role

"Molybdenum cofactor biosynthesis protein MoaA" in subsystem Molybdenum cofactor biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZQ3 at UniProt or InterPro

Protein Sequence (297 amino acids)

>MMP_RS03015 GTP 3' 8-cyclase MoaA (Methanococcus maripaludis S2)
MEDRYGRQIRSFRLSITPKCNLKCFYCHKEGRNEEHGKLMSADEIGKIVNSSLEFGVRKI
KISGGEPLLRTDLPEIISYIKNEQIKDISLTTNGILLEKYAQKLKDAGLDRVNVSLDTLD
PVQYKKITAGGNIESVKKGIEKAIEVGLTPLKVNFLAMDCTVNQLPAIMDYCRKIGAILQ
IIEFIPMEPELKHHHVDVVPIEEEIAKNADNVFTRKFMQNRKKYVIDGLEVEFVRPMDNT
EFCNHCTRIRLTYDGYLKPCLLRDDNLVDVANPLRNGEDIRKYFIKCIHEREPFCKP