Protein Info for MMP_RS02935 in Methanococcus maripaludis S2

Annotation: A24 family peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 230 transmembrane" amino acids 27 to 45 (19 residues), see Phobius details amino acids 51 to 72 (22 residues), see Phobius details amino acids 82 to 101 (20 residues), see Phobius details amino acids 113 to 134 (22 residues), see Phobius details PF01478: Peptidase_A24" amino acids 6 to 118 (113 residues), 55.1 bits, see alignment E=9.2e-19 PF06847: Arc_PepC_II" amino acids 186 to 221 (36 residues), 30.9 bits, see alignment 3.2e-11

Best Hits

Swiss-Prot: 100% identical to FLAK_METMP: Preflagellin peptidase (flaK) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K07991, archaeal preflagellin peptidase FlaK (inferred from 100% identity to mmp:MMP0555)

MetaCyc: 48% identical to preflagellin peptidase (Methanococcus voltae)
RXN-12619 [EC: 3.4.23.52]

Predicted SEED Role

"Signal peptidase, type IV - prepilin/preflagellin" in subsystem Signal peptidase

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.23.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZR9 at UniProt or InterPro

Protein Sequence (230 amino acids)

>MMP_RS02935 A24 family peptidase (Methanococcus maripaludis S2)
LIEYIIGVIGLLLASVQDFRSREIEDYIWIVLAVFGILFAIYSAITLSNYSILINSISGF
VICFILGYMMFLSGIGGGDGKILIGLGALVPKFQMPIYTSLGTLLNLNYIPNFPIMVFIN
GIFFMVFLPFVILFRNILNGARPKTGKEVILMFFGEKMKVKVAKEQKRLIMGQNDKINFF
PASDDEDFSKYGDEEEIWVTPQIPLIIPITLSYLVTPIIGDRILDLLIPF