Protein Info for MMP_RS02825 in Methanococcus maripaludis S2

Annotation: mechanosensitive ion channel family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 360 transmembrane" amino acids 18 to 39 (22 residues), see Phobius details amino acids 60 to 80 (21 residues), see Phobius details amino acids 86 to 107 (22 residues), see Phobius details amino acids 136 to 155 (20 residues), see Phobius details amino acids 162 to 192 (31 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 179 to 244 (66 residues), 78.2 bits, see alignment E=4.1e-26 PF21082: MS_channel_3rd" amino acids 252 to 334 (83 residues), 57.1 bits, see alignment E=2.1e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0534)

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZT9 at UniProt or InterPro

Protein Sequence (360 amino acids)

>MMP_RS02825 mechanosensitive ion channel family protein (Methanococcus maripaludis S2)
MIPELLEYLQNSFFYGLSYYSGLKLILVVVIGLFVSYFIEKRVKKISETTKQTWILNEET
AGLISTFVLAIFVVLALNVIESFVTYQLFGFDLKILTYSLLIIYFTYRISNRSKRYLLLK
GSQEGKFAEYRLKATVFHYSAMIIAFGIVFQMLGLTSKLGTLLVAGGITGIILGFASQTV
VANFISGIFLYFDKPLKIGDSVQIGTNSGIVNDIKMMSTRIRTWDGVLVRIPNEKVFNSE
IVNNKKYPARRVDIVVGIAYKEDAQRAMDIISKILENMTYVLVEPEFQIFVNDLGNSSVD
ISVKAWTPSEKWYDVKMELVKNIKKEFDKEKVEIPFPQRTVWFPQDLKVKIEKETGEKSE