Protein Info for MMP_RS02570 in Methanococcus maripaludis S2

Annotation: cation:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 542 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 34 to 54 (21 residues), see Phobius details amino acids 63 to 86 (24 residues), see Phobius details amino acids 92 to 111 (20 residues), see Phobius details amino acids 123 to 144 (22 residues), see Phobius details amino acids 154 to 177 (24 residues), see Phobius details amino acids 189 to 209 (21 residues), see Phobius details amino acids 215 to 231 (17 residues), see Phobius details amino acids 240 to 258 (19 residues), see Phobius details amino acids 264 to 288 (25 residues), see Phobius details amino acids 298 to 317 (20 residues), see Phobius details amino acids 328 to 348 (21 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 2 to 342 (341 residues), 190.5 bits, see alignment E=4.2e-60 PF02254: TrkA_N" amino acids 383 to 498 (116 residues), 78 bits, see alignment E=7.4e-26

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0484)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefC" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LZY9 at UniProt or InterPro

Protein Sequence (542 amino acids)

>MMP_RS02570 cation:proton antiporter (Methanococcus maripaludis S2)
MLKQPLIIGYILTGILVSPYFLNIVRFEESISTLGHYGVTILLFMVGISLNPGYFKEIGK
ISLITGLGQILFTFSIGFLISVFLGYSLIESMYISIALTFSSTIIIMKLISDKGDIDKLY
GKISIGFLIVQDIVAMAILVLISAFNVQSGAGELLFLIISKIVLILTAIYIFTKYALSNF
ISYASKNQEFLFLFSLMWCFTLASLFHLLGFSSEIGALIAGIVLAIFPERYEIASKVRPL
RDFFLILFFVVLGVQMTFETSGNFIIPAIILSIFVLFGNPIIVMILMGAFGYTKKTGFLA
GLTVAQISEFSLIIASLGLRNGHISQEIVSMITLIGIMTIAGSSYFITYSERIYALLSNY
LSIFEKKTKISEKDFKNKNTGEIILFGADRTGKNILNVIENSKERFLIIDYNPKIIKNLS
KRGYNSVYGDASNLELLNELNFKESKMLISTISDIETDILLIKTILKSNKNAIIIVIAHK
IEDAIKLYEEGASYVIMPHFLGSIHASLMIQKYGLNIEEFLKEKSNHIESLKKSQELFRH
TK