Protein Info for MMP_RS02400 in Methanococcus maripaludis S2

Annotation: site-2 protease family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 337 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 37 to 56 (20 residues), see Phobius details amino acids 87 to 108 (22 residues), see Phobius details amino acids 120 to 140 (21 residues), see Phobius details amino acids 173 to 199 (27 residues), see Phobius details PF02163: Peptidase_M50" amino acids 40 to 109 (70 residues), 44 bits, see alignment E=1.7e-15 amino acids 120 to 178 (59 residues), 39.2 bits, see alignment E=5.2e-14 PF00571: CBS" amino acids 219 to 268 (50 residues), 48.3 bits, see alignment 1e-16 amino acids 278 to 328 (51 residues), 42.9 bits, see alignment 5e-15

Best Hits

Swiss-Prot: 52% identical to Y392_METJA: Zinc metalloprotease MJ0392 (MJ0392) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01417, [EC: 3.4.24.-] (inferred from 100% identity to mmp:MMP0453)

Predicted SEED Role

"Putative zinc metalloprotease MJ0392 (EC 3.4.24.-)" (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M020 at UniProt or InterPro

Protein Sequence (337 amino acids)

>MMP_RS02400 site-2 protease family protein (Methanococcus maripaludis S2)
LQSFKIARVMGIPIELHITFILLLIVVFYFWGIEGLILYMFLFTSVVLHELGHSYVAKKY
GVKIEKILLLPIGGMAMMSEISKEGEFKIAIAGPLVSLALGTVLLGISTVTDYTLAEYPL
FQTVGGLNILLGIFNLLPAFPMDGGRVFRALLSKLTSMSYIKATKLASTVGQYFALALLI
FGLINFNVILVLIAIFIYFGASQEYRALVADTLFQDVPAKDIMSKNIVYVNSEDTVDDVL
NLMLENRFLGYPVLENGNIIGTITMNEISSTTAKTAKVKEIMSPPVMVSPEAALNELIKG
MANTDRVYVVDNGNILGIISKTDIVRTLSILGIKNNR