Protein Info for MMP_RS02135 in Methanococcus maripaludis S2

Annotation: DUF5612 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 217 PF01842: ACT" amino acids 5 to 66 (62 residues), 33.5 bits, see alignment E=3e-12 PF18462: DUF5612" amino acids 74 to 215 (142 residues), 246.5 bits, see alignment E=7.1e-78

Best Hits

Swiss-Prot: 65% identical to Y1458_METJA: Uncharacterized protein MJ1458 (MJ1458) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06862, energy-converting hydrogenase B subunit Q (inferred from 100% identity to mmp:MMP0400)

Predicted SEED Role

"Energy conserving hydrogenase Ehb protein Q"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M071 at UniProt or InterPro

Protein Sequence (217 amino acids)

>MMP_RS02135 DUF5612 domain-containing protein (Methanococcus maripaludis S2)
MQLGLTVIAEDRVGILYRLTGIISELNANIVYTQQFIVGENTGLIYMELDGVGDEENLAG
KLEKLEFVKKVETHKTMKKIFGKRVLIFGGGAQVAQVAMGAISEADRHNIRGERISVDTM
AVVGEENLADAILAIKTLPRAGVLVLAGSLMGGAITKAVEEVKKDTNIPVICLNMFGSLP
KLADLIVTDPLQAGVIAVMTVADTAKFDITKVRGRIL