Protein Info for MMP_RS02015 in Methanococcus maripaludis S2
Annotation: amidohydrolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 41% identical to MTAD_DICTD: 5-methylthioadenosine/S-adenosylhomocysteine deaminase (mtaD) from Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
KEGG orthology group: None (inferred from 100% identity to mmp:MMP0378)Predicted SEED Role
"S-adenosylhomocysteine deaminase (EC 3.5.4.28); Methylthioadenosine deaminase" (EC 3.5.4.28)
Isozymes
Compare fitness of predicted isozymes for: 3.5.4.28
Use Curated BLAST to search for 3.5.4.28
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M093 at UniProt or InterPro
Protein Sequence (427 amino acids)
>MMP_RS02015 amidohydrolase (Methanococcus maripaludis S2) MILIKNVSYYIDNNLNVHENCDILIEKVENSEIKLTTGKNLLEKLNLNQNDLKIISGEKK CAIPGLYNAHTHVPMTLLRGIADDMILQDWLNQKIWPNEAKLNKNDVYYGSLLGCLEMLR FGVTSFNEMYFFSEEILKATKEIGLNAQVSYPIIDFGTPEEQSIDKLLTSAESFVKNNVG EKNIKVGIAPHAPYTCSEETYQKCSEISNDYNVNMHTHVSETRYEVVELENKIGMRPVEY LEKIGVLNEKLHAAHCVWITKDEAKKLAKNNAKVLHCPTSNMKLASGGVMPLFELLEYGA DISVGTDGPASNNNLDILKEMKMTSLLHKAHRWDPTVAGIDTVLKMGINSESIEIKNNDI ILIDLDSAHLRPFNNIKSNIVYSAFGNDVDTVIVGGNILLENKKYKFSETFISNIYKNIQ KITEKFE