Protein Info for MMP_RS01850 in Methanococcus maripaludis S2

Annotation: phosphate ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 275 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details TIGR02136: phosphate binding protein" amino acids 25 to 273 (249 residues), 229.2 bits, see alignment E=3.1e-72 PF12849: PBP_like_2" amino acids 30 to 261 (232 residues), 129.2 bits, see alignment E=3.7e-41 PF13531: SBP_bac_11" amino acids 35 to 271 (237 residues), 31.8 bits, see alignment E=1.9e-11 PF12727: PBP_like" amino acids 53 to 221 (169 residues), 35.1 bits, see alignment E=1.2e-12

Best Hits

KEGG orthology group: K02040, phosphate transport system substrate-binding protein (inferred from 100% identity to mmp:MMP0345)

Predicted SEED Role

"Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism (TC 3.A.1.7.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0C6 at UniProt or InterPro

Protein Sequence (275 amino acids)

>MMP_RS01850 phosphate ABC transporter substrate-binding protein (Methanococcus maripaludis S2)
LNFQKIALFLVLLISISCFSGCMDNSGEVSEPVTIKMAGGTALIPIIEDISKEYMLENSN
VQIEVTGGGSGFGVKETGEGHLTIGMAGRNLKSEEKELYNDITVYKIGLDGIAIITSNEN
NISDLTTEQVQKIYSGEITNWKSVGGSDSTINVYTREEDSGTRDTFWKEGLLQSNISKKA
LMVASNGEMKSKVSSDANGIGYVSIGYVDESINTVQFNGVEPTQENVKEGIYTIYRPLNL
LTKGEPDENVKKFIEYVLSEKGQEIVKNDGFLPVN