Protein Info for MMP_RS01800 in Methanococcus maripaludis S2

Annotation: TIGR00303 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 62% identical to Y1598_METJA: UPF0284 protein MJ1598 (MJ1598) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0338)

Predicted SEED Role

"Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 2.4.2.21)

MetaCyc Pathways

adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
2-methyladeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
5-methoxy-6-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
5-methoxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
5-methylbenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
adeninyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I (3/3 steps found)
benzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP (3/3 steps found)
adenosylcobalamin biosynthesis II (aerobic) (24/33 steps found)
superpathway of adenosylcobalamin salvage from cobinamide II (6/9 steps found)
superpathway of adenosylcobalamin salvage from cobinamide I (5/8 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0D3 at UniProt or InterPro

Protein Sequence (350 amino acids)

>MMP_RS01800 TIGR00303 family protein (Methanococcus maripaludis S2)
MPIISINENGFLDKLKGTNGLFSCVISSIETTKYVGISGVNKSVIDYTPAADMELVTIGE
SLSLNHPPIDATGCPSPATITRAAVDILKIPVMTVDAGSYIKPKIPYISVDQRPTGDIQK
GLGMDNSKELLNLGKIIGNNNIYDSLVIGESVPGGTTTALGVLLGLGYDARDKISSGSVE
NPKDLKLSVVESGLKNSKSKDVFDVLNAVGDKMMPVVAGMAISAVSKGKPVLLAGGTQMA
SVLAAIKEISPKILKSGLLGISTTEFVLNDKNADLKDIIEQIGDIPLYASKFGYENSKID
GLKAYCNGSVKEGVGAGGIATYCYSNGLNPKDIREYVEKNYEIWYSKLIQ