Protein Info for MMP_RS01750 in Methanococcus maripaludis S2

Annotation: DUF63 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 268 transmembrane" amino acids 28 to 47 (20 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 89 to 109 (21 residues), see Phobius details amino acids 116 to 133 (18 residues), see Phobius details amino acids 145 to 163 (19 residues), see Phobius details amino acids 178 to 199 (22 residues), see Phobius details amino acids 211 to 232 (22 residues), see Phobius details amino acids 244 to 262 (19 residues), see Phobius details PF01889: DUF63" amino acids 7 to 268 (262 residues), 289 bits, see alignment E=3.5e-90

Best Hits

Swiss-Prot: 53% identical to Y440_METJA: Uncharacterized protein MJ0440 (MJ0440) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0328)

Predicted SEED Role

"Uncharacterized protein MJ0440"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0E3 at UniProt or InterPro

Protein Sequence (268 amino acids)

>MMP_RS01750 DUF63 family protein (Methanococcus maripaludis S2)
MNGMLLIREFIYRYYIYPIDTKQGYNLIQEITYGILLFVMVYTFYRMCLKLKIAIDRRFA
EVTVFYVILITLMRALVDAGLFPRLYYTVTPGIVVAVGIYYMLSIIISGILLKKRYYLLS
IAMAVVPILYMLFEFSSRITHPEAIVYVSGILVLSYYLLIYIVEKLKKAKIERIDKYAIF
SQLVDASATSVGIGVFGYWEQHPVPRFFMDYFGPYSIIPLKMLVVLLVLDIFNKEVKDDN
LRNILKITVMALGLAPGLRNLFRTVMGV