Protein Info for MMP_RS01745 in Methanococcus maripaludis S2

Annotation: AMP phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 505 TIGR03327: AMP phosphorylase" amino acids 4 to 502 (499 residues), 792.9 bits, see alignment E=1.1e-242 TIGR02645: putative thymidine phosphorylase" amino acids 6 to 496 (491 residues), 666.3 bits, see alignment E=2.2e-204 PF02885: Glycos_trans_3N" amino acids 91 to 152 (62 residues), 50.1 bits, see alignment E=2.8e-17 PF00591: Glycos_transf_3" amino acids 162 to 390 (229 residues), 58.1 bits, see alignment E=1.7e-19 PF07831: PYNP_C" amino acids 426 to 491 (66 residues), 53.7 bits, see alignment E=2e-18

Best Hits

Swiss-Prot: 100% identical to AMPPA_METMP: AMP phosphorylase (MMP0327) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00758, thymidine phosphorylase [EC: 2.4.2.4] (inferred from 100% identity to mmp:MMP0327)

MetaCyc: 56% identical to AMP phosphorylase (Thermococcus kodakarensis)
RXN-14699 [EC: 2.4.2.57]; 2.4.2.57 [EC: 2.4.2.57]; 2.4.2.57 [EC: 2.4.2.57]

Predicted SEED Role

"AMP phosphohydrolase" in subsystem AMP to 3-phosphoglycerate

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.4 or 2.4.2.57

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0E4 at UniProt or InterPro

Protein Sequence (505 amino acids)

>MMP_RS01745 AMP phosphorylase (Methanococcus maripaludis S2)
MLFLNAKFIDLDLGENAVIVNEDDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVQKGE
VGMLVSELAEISISEGEEVKLRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLS
NIELSAFVSSTYINGMNMDEIGEMTKRIAETGDMISWEKNLVVDIHSIGGVPGNKYALLS
IPILAAAGITIPKTSSRAITSPAGTADVMEVLTNVELKEDEIKRIVKTTNGCLVWGGGVN
LAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYSVIDIPVGKGVKIKNEAEGAKL
ARKFIELGELLNIKVECVLTYGGQPLGRAIGPALEAKEAIEALQDPKNAPKSLIEKALSL
AGILLELGGAAQIGEGQNLAWEILESGRALEKFNQIIIEQGGTPKKPEEIELGDYIEEII
APIDGYVTDINNTGITNVVKEAGAPRDKKAGLLLNSKIGNKVKKGDVLYTIYSGSEERLV
SAVNLARRVYPVKVEGMLIERISKF