Protein Info for MMP_RS01690 in Methanococcus maripaludis S2

Annotation: indolepyruvate ferredoxin oxidoreductase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 612 TIGR03336: indolepyruvate ferredoxin oxidoreductase, alpha subunit" amino acids 4 to 606 (603 residues), 733.3 bits, see alignment E=9.1e-225 PF01855: POR_N" amino acids 16 to 194 (179 residues), 69.7 bits, see alignment E=9.9e-23 PF02775: TPP_enzyme_C" amino acids 399 to 541 (143 residues), 86.1 bits, see alignment E=6.6e-28 PF00037: Fer4" amino acids 587 to 606 (20 residues), 23 bits, see alignment (E = 1.6e-08)

Best Hits

KEGG orthology group: K00179, indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC: 1.2.7.8] (inferred from 100% identity to mmp:MMP0316)

Predicted SEED Role

"Indolepyruvate oxidoreductase subunit IorA (EC 1.2.7.8)" in subsystem Aromatic amino acid interconversions with aryl acids (EC 1.2.7.8)

Isozymes

Compare fitness of predicted isozymes for: 1.2.7.8

Use Curated BLAST to search for 1.2.7.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0F5 at UniProt or InterPro

Protein Sequence (612 amino acids)

>MMP_RS01690 indolepyruvate ferredoxin oxidoreductase subunit alpha (Methanococcus maripaludis S2)
LSNKHFLMGNEAIAYGAIAAGLQFGAGYPGTPSTEVMETLIKNAKKYNYYVEWSTNEKVA
LETAIGASFSGASSIVTMKQVGLNVASDPLMSLTYLGIKGPLVLLVTDDPGPHSSQTEQD
TRSFGLFSNIPVLDPSNSQEAYEMTKYAFKISKEYETPVILRTTTRVSHRCDDVVLEELK
PSDENIEEFSKSSRWAIFPKLTAERHPILEKLQKTLSNKFSDSKFNFKTGTGKIGIITSG
ASYHYVNEAISNNKELFSVLKIGTPHPFPENKVIEFTNEVDSIIVVEELDSYLEDQLLQL
LGKQGILKPIYGKKNNIFPCCGEYSVDIVKIGINKVLDSLKLQKLEISEKLIDKNDIIPL
PVRPPNLCAGCMHRTVFYAFKEVSKELKKHNIQTIFSGDIGCYTLGNAPPLELIDTCLCM
GAGISIAGGISRTTKNSKNVAFIGDSTFFHSGIPAVINAVYNNADVTIAVLDNRTTAMTG
HQPHPGTGKTALGKPTKLIDIEGILKSCGVEFVKTVSADDFSACKEISKEVIEYNGPSAV
VFRGNCVSLVKSDKKYVIDKNKCINCKICVERLGCPAITMNDEIPEIMDNCTGCGLCKAV
CPANAVIEVTKQ