Protein Info for MMP_RS01640 in Methanococcus maripaludis S2
Annotation: 2-oxoacid:acceptor oxidoreductase subunit alpha
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00174, 2-oxoglutarate ferredoxin oxidoreductase subunit alpha [EC: 1.2.7.3] (inferred from 100% identity to mmp:MMP0306)Predicted SEED Role
"2-oxoglutarate oxidoreductase, alpha subunit (EC 1.2.7.3)" (EC 1.2.7.3)
MetaCyc Pathways
- incomplete reductive TCA cycle (6/7 steps found)
- reductive TCA cycle I (6/11 steps found)
- TCA cycle V (2-oxoglutarate synthase) (4/9 steps found)
- reductive TCA cycle II (5/12 steps found)
- TCA cycle VI (Helicobacter) (2/9 steps found)
- TCA cycle VII (acetate-producers) (2/9 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (35/56 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.7.3
Use Curated BLAST to search for 1.2.7.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M0G5 at UniProt or InterPro
Protein Sequence (570 amino acids)
>MMP_RS01640 2-oxoacid:acceptor oxidoreductase subunit alpha (Methanococcus maripaludis S2) MNLEKEVSIVLGGAAGQGIQTIEESLTKILKLSGYNVFATKEYMSRVRGGINTTEIVISS EKQRSFLKRIDLLVTFKKGVLNHLKDRISDETIILGEKENIDEEFLNNKNIIDIPIQEIS KNIGNILFSNTVGSGIILGIFDCDLDFFNKYLEDKFSKKGKEIVDKNIQAAKEGYELGKK ILKDLDLSLNIEKNEKISNEIILSGTEAVALGAAKAGCNFVSFYPMTPSTGVSTFLANHS KDLGIIVEQVEDEISAINMAIGAGYAGARSLVTTSGGGFSLMCEAVSLSGMTETPVVIYL AQRPGPSTGLPTRTAQGDLELALYSGHGEFPKIIYAPGKIEEAHKISQIAFNMADKYQVP VFVLSDEYLADTYYNLSDNELESLKKENHVVKTSLDYKRYEINENIVSKRGIPGFGEGIV LACGNEHDEFGDITEDIDLINKMTEKRNKKLDLIKKEAIEPEFIGDETYKNLIVSWGSTF YPIKDALEKLNLKDTAFLHFSQVYPISDSAEKYLKNAEKVINIELNYTGQLGKLLKREFG IEMNDSILKYDGRVFAVEELIEKIEKVLRG