Protein Info for MMP_RS01630 in Methanococcus maripaludis S2

Annotation: N-glycosylase/DNA lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 PF09171: AGOG" amino acids 12 to 231 (220 residues), 289.2 bits, see alignment E=1.2e-90

Best Hits

Swiss-Prot: 100% identical to AGOG_METMP: N-glycosylase/DNA lyase (MMP0304) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01741, DNA-(apurinic or apyrimidinic site) lyase [EC: 4.2.99.18] (inferred from 100% identity to mmp:MMP0304)

Predicted SEED Role

"8-oxoguanine DNA glycosylase, archaeal type"

Isozymes

Compare fitness of predicted isozymes for: 4.2.99.18

Use Curated BLAST to search for 4.2.99.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0G7 at UniProt or InterPro

Protein Sequence (252 amino acids)

>MMP_RS01630 N-glycosylase/DNA lyase (Methanococcus maripaludis S2)
MRNLEKINELLEIFGHFDVNFAKTMEEKIDTQYFVLENLKNSMNNDEMFIKLVILNSIVS
YQLCTTGELWWEEFSKYWSKHDANNENLGESYVNFLENSKGNKRLLNVKIKRIERITPFL
ENLNLLDFKTYYSDMEKLLENLSKYLNSKKNSKTVVFAVKMFGYASRIVFNEFFPYPMNI
EIPKDSRIEKYTLKFTDENPIKFWNEVSKTAKIPPLHIDSIIWPVLGRNFDFKSCENKLD
ENFRYLLKLTEL