Protein Info for MMP_RS01575 in Methanococcus maripaludis S2

Annotation: aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01791: DeoC
  • amino acids 39 to 274 (236 residues), 176.7 bits, E=3e-56

Best Hits

Swiss-Prot: 65% identical to DKFP_METJA: Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase (MJ1585) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01623, fructose-bisphosphate aldolase, class I [EC: 4.1.2.13] (inferred from 100% identity to mmp:MMP0293)

MetaCyc: 65% identical to fructose 1,6-bisphosphate aldolase monomer (Methanocaldococcus jannaschii)
Fructose-bisphosphate aldolase. [EC: 4.1.2.13]; RXN-10053 [EC: 4.1.2.13, 2.2.1.11]; 2.2.1.11 [EC: 4.1.2.13, 2.2.1.11]

Predicted SEED Role

"Fructose-bisphosphate aldolase, archaeal class I (EC 4.1.2.13) @ Methylglyoxal--fructose-6-phosphate transaldolase @ Methylglyoxal--fructose-1,6-bisphosphate transaldolase" (EC 4.1.2.13)

MetaCyc Pathways

• chorismate biosynthesis II (archaea) (12/12 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (16/18 steps found)
• glycolysis V (Pyrococcus) (10/10 steps found)
• 3-dehydroquinate biosynthesis II (archaea) (7/7 steps found)
• formaldehyde assimilation II (assimilatory RuMP Cycle) (8/9 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
• glycolysis II (from fructose 6-phosphate) (9/11 steps found)
• glycolysis IV (8/10 steps found)
• pentose phosphate pathway (non-oxidative branch) II (5/6 steps found)
• Calvin-Benson-Bassham cycle (10/13 steps found)
• gluconeogenesis I (10/13 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• gluconeogenesis III (9/12 steps found)
• glycolysis III (from glucose) (8/11 steps found)
• sedoheptulose bisphosphate bypass (1/2 steps found)
• homolactic fermentation (8/12 steps found)
• superpathway of anaerobic sucrose degradation (13/19 steps found)
• glycolysis VI (from fructose) (7/11 steps found)
• sucrose degradation V (sucrose α-glucosidase) (2/5 steps found)
• oxygenic photosynthesis (10/17 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (10/17 steps found)
• superpathway of hexitol degradation (bacteria) (10/18 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (10/19 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (12/22 steps found)
• 1,3-propanediol biosynthesis (engineered) (2/9 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (14/26 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (35/56 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (14/27 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (13/26 steps found)
• superpathway of N-acetylneuraminate degradation (10/22 steps found)
• ethene biosynthesis V (engineered) (12/25 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Carbon fixation in photosynthetic organisms
• Fructose and mannose metabolism
• Glycolysis / Gluconeogenesis
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 4.1.2.13

Use Curated BLAST to search for 2.2.1.11 or 4.1.2.13

Sequence Analysis Tools

See Q6M0H7 at UniProt or InterPro

Protein Sequence (308 amino acids)

>MMP_RS01575 aldolase (Methanococcus maripaludis S2)
VVKKITFEDVLIPMETPESMHDEYVQNYLKLTRNTGNLMLFAGDQKIEHLNNDFYGENIS
KDDADPEHLFKIAKNSKIGGFAVQFGLLSRYGQNYKDINYIVKLNSKTNLVDVDQKDPLS
RALLDINDILEFKKNSGVNIVGVGYTIYLGSEYESEMLSEASKIIYEAHKGGLVVILWIY
PRGKAVQNEKDPKLIAGATGVASCLGADFVKVNYPKSENPAESFKEAVMAAGRTKVVCAG
GSSTDIESFLKQLYEQIHISGASGNATGRNIHQKSLSDAVAMCNAIYAVTIDGKTVSEAL
NIYSERKS