Protein Info for MMP_RS01565 in Methanococcus maripaludis S2

Annotation: AIR synthase related protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 PF00586: AIRS" amino acids 115 to 225 (111 residues), 35.7 bits, see alignment E=1e-12 PF02769: AIRS_C" amino acids 240 to 385 (146 residues), 47.5 bits, see alignment E=2.3e-16

Best Hits

Swiss-Prot: 71% identical to Y1416_METJA: Uncharacterized protein MJ1416 (MJ1416) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07388, hydrogenase expression/formation protein (inferred from 100% identity to mmp:MMP0291)

Predicted SEED Role

"Hydrogenase expression/formation protein related"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0H9 at UniProt or InterPro

Protein Sequence (447 amino acids)

>MMP_RS01565 AIR synthase related protein (Methanococcus maripaludis S2)
MDIERYVRKCLKKGISESKIIEDGFKKVIEVKDTDEGWARRFVEAVVEEVKTTEKYRESE
DKNLKYILDCPESGITMGKMGVGSRGEGDFFVHREIARIIESTNQDTEVDSTEQDDAGVV
RANAEHVVVAVDGTHSRLSDFPFIAGFHVARAALRDVYVMGADAVAVISDVHLADDGDVS
KIFDYTAGICAVSEAIDVPLVAGSTLRVGGDMVLGDRMVSAVGAIGTIEKGEPTARKRAE
VGDVILMTEGSGGGTISTTALYYGMFDVINETINVDFLKSCKNLIENDLLKHIHVMTDVT
NGGLRGDAFEITNTAKVSLEIYKEKVNELVNPKVLEMLQKLNIDPLGVSIDSLLIIVPKD
KAGEIMEKTGAKQIGVVKEGEVSYLIDENGEKELLIPKFREAAYTPVKKVVGEQKPDNFE
EMKEKVRKTCDMAIEKKDFVVKEMFKN