Protein Info for MMP_RS01545 in Methanococcus maripaludis S2

Annotation: CBS domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00571: CBS
  • amino acids 5 to 54 (50 residues), 42.4 bits, 7.3e-15
  • amino acids 62 to 117 (56 residues), 41.2 bits, E=1.7e-14
• PF02195: ParBc
  • amino acids 147 to 224 (78 residues), 53.3 bits, E=2.5e-18

Best Hits

Swiss-Prot: 58% identical to Y188_METJA: Uncharacterized protein MJ0188 (MJ0188) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00088, IMP dehydrogenase [EC: 1.1.1.205] (inferred from 100% identity to mmp:MMP0287)

Predicted SEED Role

"CBS/parB domain-containing protein"

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (35/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (17/21 steps found)
• guanosine ribonucleotides de novo biosynthesis (3/4 steps found)
• superpathway of purine nucleotide salvage (10/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (4/6 steps found)
• inosine 5'-phosphate degradation (2/4 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (17/26 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (4/8 steps found)
• purine nucleotides degradation II (aerobic) (6/11 steps found)
• adenosine nucleotides degradation I (3/8 steps found)
• ureide biosynthesis (2/7 steps found)
• purine nucleotides degradation I (plants) (4/12 steps found)
• superpathway of purines degradation in plants (4/18 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.205

Use Curated BLAST to search for 1.1.1.205

Sequence Analysis Tools

See Q6M0I3 at UniProt or InterPro

Protein Sequence (264 amino acids)

>MMP_RS01545 CBS domain-containing protein (Methanococcus maripaludis S2)
MVYAEEYMTKKVHSITPDATVSDIIKLVKETTHDTFPVVVNSKVKGIVSVHDLIGKDELD
EVSEFMTPRDDMIVTKPHTKIMDVGRIMFRTGFSKLPIVDENNNILGIITNTDVIRSQIE
KTTPKKLKKIVNSYINLGYEVTTKRETIQIDDLIPTQANVYEDELYGRAYELKRGLAEPI
IVIKTNVNEKYILVDGHHRAVAACLSNIKELEAHVLEINTDKTMGIEKTAEKQGLKSLKD
IKILDEEKMNCSSAYKLRANILEL