Protein Info for MMP_RS01375 in Methanococcus maripaludis S2

Annotation: bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 TIGR00197: YjeF family N-terminal domain" amino acids 31 to 241 (211 residues), 138.1 bits, see alignment E=3.2e-44 PF03853: YjeF_N" amino acids 51 to 210 (160 residues), 87 bits, see alignment E=1.5e-28 TIGR00196: YjeF family C-terminal domain" amino acids 245 to 503 (259 residues), 247.4 bits, see alignment E=1.7e-77 PF01256: Carb_kinase" amino acids 270 to 500 (231 residues), 176.4 bits, see alignment E=7.3e-56

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0254)

Predicted SEED Role

"NAD(P)HX epimerase / NAD(P)HX dehydratase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0L6 at UniProt or InterPro

Protein Sequence (507 amino acids)

>MMP_RS01375 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase (Methanococcus maripaludis S2)
MKDIKCFQKTGNILKFEELRAKLKINDKNDVSPLEIKVIDENSEQYGISKETLMENAGRA
VYEEIVNLNVDFSKTYLFCGTGNNGGDGFVIARHLANNFATFVVLIGNERKIKTSETQRN
FNTVKNMEFFGNLDYANILDDERAVELLKTIEKELENKQNDHILIIDAMLGTGITGILKN
PYSTIVDYLNVLKSKYSKKLKMVSVDIQTGNLNADLEVILHKRKFENKNKNFVVKDIGIP
KYIENMVGKGDFYLLNERKQNSHKGQNGNVLVIGGSKEYHGAPVFSALAASKFADIVTVA
SVSNVMNTVSNYPELMPYELTGDYIVQNHVDELLELSKNYDCVVLGSGISVNSDTKEFVN
SYLNETNGKVVIDADAIKLIDYSNFKFKNNFIFTPHKKEFEYIENYIESSGFKSTVVLKG
SLDIIFNSNNIKMNITGNQGMTVGGTGDILCGIIGAIYACNDAFPSACCGTYINGYCGDL
LEKEYGYYYNSTDIIKILPKALKELLY