Protein Info for MMP_RS01215 in Methanococcus maripaludis S2

Annotation: sodium/proline symporter PutP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 492 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 46 to 63 (18 residues), see Phobius details amino acids 68 to 91 (24 residues), see Phobius details amino acids 125 to 147 (23 residues), see Phobius details amino acids 161 to 184 (24 residues), see Phobius details amino acids 194 to 214 (21 residues), see Phobius details amino acids 239 to 262 (24 residues), see Phobius details amino acids 282 to 304 (23 residues), see Phobius details amino acids 315 to 337 (23 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 400 to 420 (21 residues), see Phobius details amino acids 427 to 445 (19 residues), see Phobius details amino acids 452 to 472 (21 residues), see Phobius details TIGR02121: sodium/proline symporter" amino acids 7 to 490 (484 residues), 649 bits, see alignment E=4.7e-199 PF00474: SSF" amino acids 36 to 435 (400 residues), 349.6 bits, see alignment E=1.2e-108 TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 36 to 435 (400 residues), 332 bits, see alignment E=5.9e-103

Best Hits

Swiss-Prot: 48% identical to PUTP_BACSU: High-affinity proline transporter PutP (putP) from Bacillus subtilis (strain 168)

KEGG orthology group: K11928, sodium/proline symporter (inferred from 100% identity to mmp:MMP0221)

Predicted SEED Role

"Sodium/proline symporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0P8 at UniProt or InterPro

Protein Sequence (492 amino acids)

>MMP_RS01215 sodium/proline symporter PutP (Methanococcus maripaludis S2)
MISENLSIVLVFILYLLVVMGVGMYFYRRNETISDYVLGGRKLNSWVAALSAQASDMSGW
LLMGLPGVAYLSGMSEIWIGVGLAIGTYLNWKFVAERLRRYTEIAKDSITIPVYLENRFR
DQSKLLRIVSAFFIMLFFLLYTSSGLVAGGKLFNLVFGVDYTLAVTIGALVIIGYTFLGG
FLAVSWTDFIQGSLMFIAIFLIPIMGISQVGGIDATMNAWNSISPDYLNPFTNLDGESLG
IMGLASALAWGLGYFGMPHILVRFMAIKSADKVPKARKIATTWVVISLFMAVLVGMVGAV
ALGAPLDDPEHVFMAMAQGLFPSLIAGLFLAGVLAAIMSTADSQLLVTASAITEDIYALL
NKNASQKELLWISRFAVIVVAAIAYYFAIVPGSSVMGLVSYAWAGFGGAFGPVILLSLYW
KRMTRNGALAGLLSGGFMVILWKNLSGGIFDLYEIVPAFLLASVMITVVSLMDKEPSLEI
QEEFDRAVSEMK