Protein Info for MMP_RS01205 in Methanococcus maripaludis S2

Annotation: manganese-dependent inorganic pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 307 PF01368: DHH" amino acids 2 to 144 (143 residues), 69.6 bits, see alignment E=3.2e-23 PF02833: DHHA2" amino acids 181 to 303 (123 residues), 121.2 bits, see alignment E=3.6e-39

Best Hits

Swiss-Prot: 68% identical to PPAC_METJA: Manganese-dependent inorganic pyrophosphatase (ppaC) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 100% identity to mmp:MMP0219)

Predicted SEED Role

"Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0Q0 at UniProt or InterPro

Protein Sequence (307 amino acids)

>MMP_RS01205 manganese-dependent inorganic pyrophosphatase (Methanococcus maripaludis S2)
MMYVVGHKNPDSDSICSAIALAYFLDAFPARLGELNPESQFILKRFGLMEPELIKTAKGK
ELFLVDHAEKSQNLDDFDKGKLIGIIDHHKIGISTTEPIIYLSKPVGSTASVISELYFRG
ILDIIGGKNKELKADIAGVLLSAILSDTLLFKSPTATPLDKELAEKLADIAGISDITAYG
MEMLTAKSTVGKMTPEEILHIDYKPFDMSGKKVGIGQAEVIDMSEVASKKEAIQNLIDEM
IEKEGYDMVLFLVTDIMKEGSEVLVAGNKSSFETAFELKLDGKSVFIDGLMSRKKQVVPP
LEKYYSN