Protein Info for MMP_RS01030 in Methanococcus maripaludis S2
Annotation: MTAP family purine nucleoside phosphorylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 71% identical to MTIP_METJA: Probable S-methyl-5'-thioinosine phosphorylase (MJ0060) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
KEGG orthology group: K00772, 5'-methylthioadenosine phosphorylase [EC: 2.4.2.28] (inferred from 100% identity to mmp:MMP0185)MetaCyc: 49% identical to guanosine phosphorylase (Thermococcus kodakarensis)
Purine-nucleoside phosphorylase. [EC: 2.4.2.1, 2.4.2.15]
Predicted SEED Role
"5'-methylthioadenosine phosphorylase (EC 2.4.2.28)" in subsystem Methionine Salvage (EC 2.4.2.28)
MetaCyc Pathways
- superpathway of guanine and guanosine salvage (3/3 steps found)
- guanine and guanosine salvage I (2/2 steps found)
- S-methyl-5'-thioadenosine degradation II (1/1 steps found)
- superpathway of purine nucleotide salvage (10/14 steps found)
- 5'-deoxyadenosine degradation I (2/3 steps found)
- adenine and adenosine salvage V (2/3 steps found)
- adenine and adenosine salvage I (1/2 steps found)
- guanosine nucleotides degradation III (2/4 steps found)
- inosine 5'-phosphate degradation (2/4 steps found)
- purine deoxyribonucleosides degradation II (1/3 steps found)
- adenosine nucleotides degradation II (2/5 steps found)
- adenine and adenosine salvage III (1/4 steps found)
- purine deoxyribonucleosides degradation I (1/4 steps found)
- purine nucleotides degradation II (aerobic) (6/11 steps found)
- nucleoside and nucleotide degradation (halobacteria) (2/6 steps found)
- purine ribonucleosides degradation (2/6 steps found)
- L-methionine salvage cycle III (5/11 steps found)
- ureide biosynthesis (2/7 steps found)
- nucleoside and nucleotide degradation (archaea) (4/10 steps found)
- superpathway of purine deoxyribonucleosides degradation (1/7 steps found)
- salinosporamide A biosynthesis (2/15 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Methionine metabolism
- Nicotinate and nicotinamide metabolism
- Purine metabolism
- Pyrimidine metabolism
- Urea cycle and metabolism of amino groups
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.4.2.1 or 2.4.2.15 or 2.4.2.28
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M0T3 at UniProt or InterPro
Protein Sequence (253 amino acids)
>MMP_RS01030 MTAP family purine nucleoside phosphorylase (Methanococcus maripaludis S2) LIGIIGGTGISSILNKGEERIIDTKYGKSKVLIDKESDVVLLFRHGAEHNTPPHKINYRA NICALKMLGVERILALSSVGSLREDVVPGDFLIPNDFLEFTKARKSTFYDGEDGKVVHVD VTEPYCPELKEVAKKILKKRDYKFNEGVYVCTEGPRFETKTEIQIYKNWGHVVGMTAYPE VVLAREMEMCYTSICNVSNYAAGISKNVLTVDEVLETLKEMEEKILNVVDDFINYEFKER TCFCKSALENAVM