Protein Info for MMP_RS01020 in Methanococcus maripaludis S2

Annotation: 3 4-dihydroxy-2-butanone-4-phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 247 TIGR00506: 3,4-dihydroxy-2-butanone-4-phosphate synthase" amino acids 21 to 240 (220 residues), 277.5 bits, see alignment E=2.8e-87 PF00926: DHBP_synthase" amino acids 25 to 239 (215 residues), 207.1 bits, see alignment E=9.4e-66

Best Hits

Swiss-Prot: 71% identical to RIBB_METJA: 3,4-dihydroxy-2-butanone 4-phosphate synthase (ribB) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K02858, 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC: 4.1.99.12] (inferred from 100% identity to mmp:MMP0183)

MetaCyc: 71% identical to 3,4-dihydroxy-2-butanone 4-phosphate synthase monomer (Methanocaldococcus jannaschii)
3,4-dihydroxy-2-butanone-4-phosphate synthase. [EC: 4.1.99.12]

Predicted SEED Role

"3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12)" (EC 4.1.99.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.99.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0T5 at UniProt or InterPro

Protein Sequence (247 amino acids)

>MMP_RS01020 3 4-dihydroxy-2-butanone-4-phosphate synthase (Methanococcus maripaludis S2)
VTTDSKNARNSEVKIQGDEKISNVEKAIDALKSGKMVLLYDSDDREGETDMVVASEFITP
EYIREMRKNAGGLICTCLHSDFCDKLGIPFMVDILDVASEKYPVLKELYPNDIPYDEKST
FALYANHRTTFTGITDNDRALTVKKITELCSEERFKDFGKEFRCPGHVAFLRATEGLVKN
RQGHTEMTVALAEMAGLTPITTICEMMGDNGKAMSKDLVKKYAEENGLVTINGQELIEYY
LKEFSKE