Protein Info for MMP_RS00975 in Methanococcus maripaludis S2

Annotation: HD domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 PF01966: HD" amino acids 53 to 151 (99 residues), 54 bits, see alignment E=2e-18 PF19276: HD_assoc_2" amino acids 165 to 373 (209 residues), 157.3 bits, see alignment E=4.3e-50

Best Hits

Swiss-Prot: 50% identical to Y1154_METJA: Uncharacterized protein MJ1154 (MJ1154) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06885, (no description) (inferred from 100% identity to mmp:MMP0174)

Predicted SEED Role

"Putative dNTP triphosphohydrolase, Archaeal subgroup"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0U4 at UniProt or InterPro

Protein Sequence (458 amino acids)

>MMP_RS00975 HD domain-containing protein (Methanococcus maripaludis S2)
MSKLKIIRDPIHKDIKLNEEEISIVDMPEIQRLRNIKQTGLTCLVYPSANHTRFEHSIGT
MHVAGEIAKNLENIDKNLTKIVALLHDIGHPPFSHTLEVAGYDHEEFTKEKIKRMNFENY
TSKEVLDVYSSKGLEGSLIHGDVDADRMDYLVRDSHHTGVAYGSIDIPRLIRSIVVIEDT
NKLGIIEKGRTTVESLLTARYQMYPTVYMHPTSRISETMIKNATIDAIKDDIFKLRDLSL
MDDIDLICTLRRSEGSSNEIMRKIDKRDLFKSISVQRYNELSPKERWNLINLSENELGII
ENEMSDFFGSRIFLDIPKPPKMAEHRITVIMGDKKQRLDEISPLAESLKDAYKKSWSVMV
YSEPETAKKSSEIVKDKNKFLFDFISDEIIDNSILNVLNEQGTVQGVTKLAGLVKKSPND
TEFHSELQKLIFCGLVDKKVEPVRGTYRYDYTAAKLDD