Protein Info for MMP_RS00940 in Methanococcus maripaludis S2

Annotation: daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 322 TIGR01188: daunorubicin resistance ABC transporter, ATP-binding protein" amino acids 11 to 299 (289 residues), 366.7 bits, see alignment E=4.7e-114 PF00005: ABC_tran" amino acids 19 to 162 (144 residues), 121.7 bits, see alignment E=5.3e-39 PF13732: DUF4162" amino acids 217 to 297 (81 residues), 34.1 bits, see alignment E=5.7e-12

Best Hits

KEGG orthology group: K09687, antibiotic transport system ATP-binding protein (inferred from 100% identity to mmp:MMP0167)

Predicted SEED Role

"Daunorubicin resistance ATP-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M0V1 at UniProt or InterPro

Protein Sequence (322 amino acids)

>MMP_RS00940 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein (Methanococcus maripaludis S2)
MHAIEVKNLVKKFDTNVAVNNVSFSVNKGEIFAFLGPNGAGKSTTINILTTLLKATSGSA
VISGFDASKDPKKVRKTIGIVFQDSTLDNQLTAYENLYIHGKIYGYKGEILKNRIDELLD
FVELLEFKDKIVRNFSGGMVRRLEIARSLIHEPEILFLDEPTIGLDPQTRSHIWEYIKKM
QAKNNMTIFLTTHYMEEAELLADKVAIIDNGKIIAEGTVNELKKIVGNDCISVKFEEIPK
NLSFENCELKENGKVIYYTENADLKIPKIFEFAHENGLKIQEISYKKPNLNDVFIKLTGR
EIRSEKDKNQKSLLPMGKRRRF