Protein Info for MMP_RS00830 in Methanococcus maripaludis S2
Annotation: purine phosphoribosyltransferase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to HPRT_METMP: Hypoxanthine/guanine phosphoribosyltransferase (hpt) from Methanococcus maripaludis (strain S2 / LL)
KEGG orthology group: K00759, adenine phosphoribosyltransferase [EC: 2.4.2.7] (inferred from 100% identity to mmp:MMP0145)Predicted SEED Role
"Adenine phosphoribosyltransferase (EC 2.4.2.7)" in subsystem Purine conversions or cAMP signaling in bacteria (EC 2.4.2.7)
MetaCyc Pathways
- superpathway of guanine and guanosine salvage (3/3 steps found)
- guanine and guanosine salvage I (2/2 steps found)
- superpathway of purine nucleotide salvage (10/14 steps found)
- adenine and adenosine salvage I (1/2 steps found)
- adenine and adenosine salvage II (1/2 steps found)
- guanine and guanosine salvage II (1/2 steps found)
- adenine salvage (1/3 steps found)
- glyphosate degradation III (2/7 steps found)
- (aminomethyl)phosphonate degradation (2/8 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.7
Use Curated BLAST to search for 2.4.2.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M0X3 at UniProt or InterPro
Protein Sequence (185 amino acids)
>MMP_RS00830 purine phosphoribosyltransferase family protein (Methanococcus maripaludis S2) MSKLLEESLKTCPIVKRGEYHYFIHPISDGVPLVEPELLRDVSTRVIKMIDTDVDKIVTA EAMGIPIVTAVSIATDIPYVIMRKREYLLEGEIPVHQETGYSKGELYLNGINKGDKVIIL DDVISTGGTLVAIINALKRAGADIKDVLCIIDRGNGQNIVEEKTGYKVKTIVKIEVVDGK VNILE