Protein Info for MMP_RS00530 in Methanococcus maripaludis S2

Annotation: tRNA pseudouridine(54/55) synthase Pus10

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 470 TIGR01213: tRNA pseudouridine(54/55) synthase" amino acids 5 to 463 (459 residues), 481.4 bits, see alignment E=9e-149 PF02926: THUMP" amino acids 106 to 222 (117 residues), 39.3 bits, see alignment E=6.8e-14 PF21238: Pus10_C" amino acids 224 to 461 (238 residues), 219.4 bits, see alignment E=5.2e-69

Best Hits

KEGG orthology group: K07583, hypothetical protein (inferred from 100% identity to mmp:MMP0094)

Predicted SEED Role

"tRNA pseudouridine 55 synthase Archaea"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M124 at UniProt or InterPro

Protein Sequence (470 amino acids)

>MMP_RS00530 tRNA pseudouridine(54/55) synthase Pus10 (Methanococcus maripaludis S2)
MNIDYSVLKKYPLCDRCFGRLYGKLIRSSNFDRGHALKLAKAIELEEDLRTALEKMNETP
ENSEVNPTDLEKLEEIKELMYALHKTGTSGIKLDLIDDIEKYETKFKNEAEYEKNEECDE
LCPWCKGIFEPENIEKVAENVVEALSEYEFDSFLVGTKLPKRFKELENEIETPFMESIRQ
EFGRELGKVVVPLIKRRVDKENPDIVVMVNPYNQKVTLQVNPVFIKGRYKKLVRGIPQSH
WDCRSCRGKGCEKCNFTGKQYMTSVEEIIAEPFMDVMKGSSEALHGAGREDIDVRMLGHG
RPFVIEIKEPKIRKVNLEELASKVNESGNVEIINVEYGVKKDVHFFKNEPHKKTYLAHVE
CEEKVSNEEVAELVKKLEDLTIDQRTPDRVSHRRADLVRVRKVYKAWPHMIDDYNFELKI
FCDGGLYIKELINSDEGRTTPSVSELLNKKCICKFLDVLDVHDYEDAENI