Protein Info for MMP_RS00475 in Methanococcus maripaludis S2

Annotation: Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 359 PF00037: Fer4" amino acids 11 to 32 (22 residues), 31.5 bits, see alignment (E = 2.8e-11) PF04422: FrhB_FdhB_N" amino acids 104 to 179 (76 residues), 77.9 bits, see alignment E=1.3e-25 PF04432: FrhB_FdhB_C" amino acids 188 to 336 (149 residues), 151.2 bits, see alignment E=5e-48

Best Hits

KEGG orthology group: K00441, coenzyme F420 hydrogenase beta subunit [EC: 1.12.98.1] (inferred from 100% identity to mmp:MMP0083)

Predicted SEED Role

"Putative coenzyme F420-dependent oxidoreductase MJ1349" in subsystem Coenzyme F420 hydrogenase

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.12.98.1

Use Curated BLAST to search for 1.12.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M135 at UniProt or InterPro

Protein Sequence (359 amino acids)

>MMP_RS00475 Coenzyme F420 hydrogenase/dehydrogenase  beta subunit C-terminal domain (Methanococcus maripaludis S2)
MKSYLNLKEEVWDKETCSGCGACVSVCPTENIYFKQQSPVQFDCDECACIIVPTENGESP
ISAEFCKVTLYDVNCGACYNACPRTKERHIFNLEKVPGRVIENYKAKSTLETKNIQSGGV
VTAILANAFDEDLIDGAIVMMEDKWTMDPKSYLATSKEDVLKTAGSRYNWNVPILEVLKE
AVMVKKLNKIAVVGTPCVINAVYQMMATNNDLVEPFKKAIRLKISLFCFETFDYDKMLKK
LKEVEVNPWDIKKMEIDKGKLIVSTIHGNVFNFKIDEMDEYVRKGCKVCRDFTGISSDIS
VGNVGTPEGYSTVLVRNKWGKGFFDRAVINGYVSVEGEASIDPVISLSKKKMERKDIEF