Protein Info for MMP_RS00450 in Methanococcus maripaludis S2

Annotation: 4Fe-4S binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 281 PF03460: NIR_SIR_ferr" amino acids 16 to 81 (66 residues), 63.6 bits, see alignment E=4.5e-21 PF01077: NIR_SIR" amino acids 90 to 280 (191 residues), 104.9 bits, see alignment E=1.2e-33 PF00037: Fer4" amino acids 158 to 181 (24 residues), 21.7 bits, see alignment (E = 5.5e-08) PF13237: Fer4_10" amino acids 158 to 204 (47 residues), 26.3 bits, see alignment 2.2e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0078)

Predicted SEED Role

"Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits" in subsystem Anaerobic respiratory reductases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M140 at UniProt or InterPro

Protein Sequence (281 amino acids)

>MMP_RS00450 4Fe-4S binding protein (Methanococcus maripaludis S2)
MNKNEIANLKMQGFILQNDGKHFALRIKTDAGCMDSEKIDKLSEISKKYGRNYISFTVRL
CVEIPWINYEDIPKIKEELKNLSLISGGTGNTVRPLVACKGTVCTHGLIDSQKICNELDS
LFFGKKLPHKFKIGISGCPNNCAKAQLNDIGIIGQRIPKINEENCNGCTLCLKSCSVDAI
TIVDKKAVIDYEKCVNCGKCGKSCKRKCISLKDGVLISVGGKFGKKYKIGENIGIYDAPN
LEKIVSEIMDYFKENADSHERFGDTIDRTGISSLKEKLKDY