Protein Info for MMP_RS00435 in Methanococcus maripaludis S2

Annotation: CPBP family intramembrane metalloprotease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 269 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 55 to 75 (21 residues), see Phobius details amino acids 81 to 102 (22 residues), see Phobius details amino acids 123 to 148 (26 residues), see Phobius details amino acids 219 to 244 (26 residues), see Phobius details PF02517: Rce1-like" amino acids 184 to 264 (81 residues), 45.7 bits, see alignment E=3.2e-16

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP0075)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M143 at UniProt or InterPro

Protein Sequence (269 amino acids)

>MMP_RS00435 CPBP family intramembrane metalloprotease (Methanococcus maripaludis S2)
MSDVNYVFGLSVYAASFLSVLLIRNQGFFKKFTKLLKMDLSFDNSIHKISLSLSTYILLN
PVIAFASGAGLIIILSDFLEILDIAAFQLIILVYAFVGIGFGTRKNLKQSIKRLDIKIPS
LKYAIFGVILLLMVDKFIWGLFDFFIYFFQSMDPAISEHIAEHAVVESSNVNEVVSTIKT
SASTPLKIVFLSIIVGISEELMFRGALQPRFGNIYTSLLFASLHAQYLSSMVLLDVFIIS
YILGMIKERKSTSTTILIHIFYDVLSLIF