Protein Info for MMP_RS00355 in Methanococcus maripaludis S2

Annotation: translation initiation factor IF-6

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 227 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR00323: putative translation initiation factor eIF-6" amino acids 4 to 224 (221 residues), 221.8 bits, see alignment E=3.3e-70 PF01912: eIF-6" amino acids 5 to 205 (201 residues), 201.3 bits, see alignment E=5.6e-64

Best Hits

Swiss-Prot: 100% identical to IF6_METMP: Translation initiation factor 6 (eif6) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K03264, translation initiation factor 6 (inferred from 100% identity to mmp:MMP0061)

Predicted SEED Role

"Eukaryotic translation initiation factor 6" in subsystem Translation initiation factors eukaryotic and archaeal

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M156 at UniProt or InterPro

Protein Sequence (227 amino acids)

>MMP_RS00355 translation initiation factor IF-6 (Methanococcus maripaludis S2)
MIMKTYFSGVSTLGVHSLATEDYGFFPLSVDQKTMERMKNVLDIPATQLNISNSSLIGSL
CVGNSNGLLVPNITTEKELELIKMFLKENSLDVNLERLKAKNTAFGNLILTNNKGCIISE
ELSRFRKTIEDVLDVESGVGNYAELPTVGSNGVATDKGCLVHPLTDELELEWIQDILRVD
YVERGTANRGVTSVGACILANTKGAVVGGDTSGPEILKIEEALDLID