Protein Info for MMP_RS00220 in Methanococcus maripaludis S2
Annotation: GTP cyclohydrolase MptA
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to MPTA_METMP: GTP cyclohydrolase MptA (mptA) from Methanococcus maripaludis (strain S2 / LL)
KEGG orthology group: K09007, hypothetical protein (inferred from 100% identity to mmp:MMP0034)MetaCyc: 66% identical to GTP cyclohydrolase monomer (Methanocaldococcus jannaschii)
RXN-10063 [EC: 3.5.4.39]
Predicted SEED Role
"GTP cyclohydrolase I (EC 3.5.4.16) type 2" in subsystem Folate Biosynthesis or Queuosine-Archaeosine Biosynthesis (EC 3.5.4.16)
MetaCyc Pathways
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus) (3/4 steps found)
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus) (5/7 steps found)
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium) (2/3 steps found)
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I (3/5 steps found)
- erythro-tetrahydrobiopterin biosynthesis I (2/4 steps found)
- threo-tetrahydrobiopterin biosynthesis (2/4 steps found)
- drosopterin and aurodrosopterin biosynthesis (4/7 steps found)
- preQ0 biosynthesis (1/4 steps found)
- tetrahydromonapterin biosynthesis (1/4 steps found)
- superpathway of tetrahydrofolate biosynthesis (4/10 steps found)
- superpathway of tetrahydrofolate biosynthesis and salvage (5/12 steps found)
- superpathway of chorismate metabolism (25/59 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.5.4.16 or 3.5.4.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6M183 at UniProt or InterPro
Protein Sequence (315 amino acids)
>MMP_RS00220 GTP cyclohydrolase MptA (Methanococcus maripaludis S2) MQCNDVQATEPDIKVSLTRVGVTNLKKLVKLKRKNKRDIVLLPTFEVFVDLPSSQKGIHM SRSPEVIEEVVENILLEKEIYGVEDLSVEIVMKLFEKHEYATRAEVMLYSDYMMEEKSPV TKKDSQEIGKIIARAYGVKDSNGKIDVKKMVGAEVVGITACPCAQNMLKENAVVSLTEKG FSSEDIEKILDSVTIATHNQRGIGTVMIEVPNGYTVGISKIIKIIKDSMSGEVYELLKRS DEAFVVEAAHKNPKFVEDCAREMIKRVVDVFDYLPEDTQVLVRQVNKESIHRHDAFAERN STIRELRDELKTLTN