Protein Info for MMP_RS00130 in Methanococcus maripaludis S2

Annotation: nickel-responsive transcriptional regulator NikR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 141 PF01402: RHH_1" amino acids 6 to 44 (39 residues), 43.3 bits, see alignment E=2.4e-15 PF08753: NikR_C" amino acids 57 to 132 (76 residues), 117.9 bits, see alignment E=1.8e-38

Best Hits

Swiss-Prot: 100% identical to NIKR_METMP: Putative nickel-responsive regulator (MMP0020) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K07722, CopG family transcriptional regulator, nickel-responsive regulator (inferred from 98% identity to mmx:MmarC6_0929)

Predicted SEED Role

"Nickel responsive regulator NikR" in subsystem Transport of Nickel and Cobalt

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6M197 at UniProt or InterPro

Protein Sequence (141 amino acids)

>MMP_RS00130 nickel-responsive transcriptional regulator NikR (Methanococcus maripaludis S2)
MVDMDRISISLPTNLLAEFDEIIEERGYASRSEAIRDSIRDYLIKHKWIHSLEGERAGTI
SIIYDHHSTDVMEKLTNIQHDYEKLIVATIHMHLDHDHCMEVVLVKGDAGEIKELTDKLT
SQKGVKQVKLTVMVPGGNIPQ