Protein Info for MMP_RS00085 in Methanococcus maripaludis S2

Annotation: DNA cytosine methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00145: DNA_methylase
  • amino acids 1 to 58 (58 residues), 41.5 bits, E=5.8e-15
  • amino acids 80 to 351 (272 residues), 125.8 bits, E=1.3e-40

Best Hits

KEGG orthology group: K00558, DNA (cytosine-5-)-methyltransferase [EC: 2.1.1.37] (inferred from 100% identity to mmp:MMP0011)

Predicted SEED Role

"DNA-cytosine modification methylase MJ0563 (EC 2.1.1.37)" (EC 2.1.1.37)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.37

Sequence Analysis Tools

See Q6M1A5 at UniProt or InterPro

Protein Sequence (355 amino acids)

>MMP_RS00085 DNA cytosine methyltransferase (Methanococcus maripaludis S2)
MNFIDLFCGCGGFSRGFVEMGFKPLLAIELDENAANSYALNYNGTVFEKKLNDILEKDVY
FKLEDFLVQDDIEEFKKSNNYENLNPVVINEDIREINSKYITNKIKDTSYSKIDVIIGGP
PCEGYTGANPKRERSPFNRLYRDPVGRLVLDYIRIVGDISPEVFVMENVPGILNYETREN
IEKEFSRAGYDELYFHVFDSENYGNPSFRKRVIILNIPLNLEKTDNVDVKTALSNIDRNA
LNNEKYPLPEKIAKSIHKIKIGGSAVKFKACGGVLDNYIRLSMEGNAETVMGKRRFIHPE
EDRLLTVREQARLMSYPDTHIFAGGITAQYNQVGESVPPSLSLAIAKEVKKYFNK