Protein Info for MMJJ_RS08845 in Methanococcus maripaludis JJ

Annotation: right-handed parallel beta-helix repeat-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05048: NosD
  • amino acids 466 to 663 (198 residues), 27.9 bits, E=2.3e-10
  • amino acids 710 to 830 (121 residues), 47.3 bits, E=2.7e-16
• PF13229: Beta_helix
  • amino acids 511 to 665 (155 residues), 35.3 bits, E=1.3e-12
  • amino acids 646 to 791 (146 residues), 34.9 bits, E=1.8e-12
• PF05124: S_layer_C
  • amino acids 929 to 1002 (74 residues), 24.1 bits, 3.8e-09

Predicted SEED Role

"N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)" in subsystem Peptidoglycan Biosynthesis or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.3.1.157, EC 2.7.7.23)

MetaCyc Pathways

• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• O-antigen building blocks biosynthesis (E. coli) (7/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (3/6 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (3/7 steps found)
• chitin biosynthesis (4/9 steps found)
• peptidoglycan recycling I (3/14 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.157, 2.7.7.23

Use Curated BLAST to search for 2.3.1.157 or 2.7.7.23

Protein Sequence (1028 amino acids)

>MMJJ_RS08845 right-handed parallel beta-helix repeat-containing protein (Methanococcus maripaludis JJ)
MGGWTAHAFIVIDKPGEYTVTTGFANNSLDSNSIVFLINNTENVTLDCNEMSFTTNTTNS
SILVYAYNSSNIVVKNMNANWSKDTIIFENVNDSTIENSEIITEGYSIKLEDSYGATISG
NDITVANGEYYGIYVDGNLENGTIFGNTINVTNNNNVCGIYTVSNITNSVISGNTITVNT
DRNAYAICADEYIVDSTIENNVIDLVAGDDGYTEALGISAYDEDILNTTISGNNITAEAY
WWACGIDAYYVMYSEIENNVINVTARGNDEVYADGIYADYNITNNVISGNNITAYSNDWA
CGIDAYSGDIVDSTIEDNVIDVYVYDYYNYGEAFGIYAYYNINNTEILRNTLTANASYEA
YGICTSDNDIVDSTIEDNVIDLIANGEYFYENLYAYTYAICADDYINNSVISRNIITAES
CYETDGIEAYDESIIDSTIEDNVIDLIATGDSNYIYAIYADEYTINSSISGNTITANASD
EAFGVYLYYYVTNTTISDNQVTIISESDSEDEAYGIYLYYGAETSIISSNSVITYGNYSH
GIEFDDYGDIINVTISDNTITTYGEDAYGISIEYDMYDSIITGNTVNTFGNDSYGIYTYY
DIYDSKISDNTITTYGDYAYGIELYDDDYYNVTLAQNTVTTYGEDAYGISIEYDMYDSII
TGNTVNTFGNDSYGIYTYYSVTNTTISSNTVTTEGSWAYGIYIYDDPLIDSTISDNAVTT
AGYEAYGIYIEYGAENSNISGNTVITNGEDTYALYLYDVTTSSIFENTFTSGDYAIYINS
SEENRFYLNNIDGLLNNGTDNYFVSSETITYSYNGKSYTSILGNYWVGYDESDTNGDGII
DTPYTLNGTNDTKPLADMWNDGEIGNYVAPSRSSGGSGRSYDSDISDEIESKVIKNFVSS
ATVLFGNGIDEQYAVQLRERVTDANGYTISGNAVIVGGPNANGFAKEYNDQFEMPISNDY
PGENRGIIQVMDIQDNSGTIIRSYTIVYIAGSDRLGTQAALEYFKTLDELPEGPIMIEWT
ANGPVVVE