Protein Info for MMJJ_RS08780 in Methanococcus maripaludis JJ

Annotation: D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02199: bifunctional protein RfaE, domain II
  • amino acids 13 to 153 (141 residues), 207.2 bits, E=9.2e-66
• TIGR00125: cytidyltransferase-like domain
  • amino acids 23 to 88 (66 residues), 66.7 bits, E=1.6e-22
• PF01467: CTP_transf_like
  • amino acids 25 to 120 (96 residues), 70.6 bits, E=7.9e-24

Best Hits

KEGG orthology group: None (inferred from 68% identity to mae:Maeo_0401)

MetaCyc: 49% identical to glycerol-3-phosphate cytidylyltransferase (Aquifex aeolicus)
Glycerol-3-phosphate cytidylyltransferase. [EC: 2.7.7.39]

Predicted SEED Role

"ADP-heptose synthase (EC 2.7.-.-) / D-glycero-beta-D-manno-heptose 7-phosphate kinase" in subsystem LOS core oligosaccharide biosynthesis (EC 2.7.-.-)

MetaCyc Pathways

• ADP-L-glycero-β-D-manno-heptose biosynthesis (4/5 steps found)
• 1-(sn-glycero-3-phospho)-1D-myo-inositol biosynthesis (1/3 steps found)
• lipid A-core biosynthesis (P. gingivalis) (1/7 steps found)
• poly(3-O-β-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis (2/10 steps found)
• poly(glycerol phosphate) wall teichoic acid biosynthesis (2/11 steps found)
• poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis) (2/12 steps found)
• poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus) (2/14 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism
• Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
• Lipopolysaccharide biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.7.-.-

Use Curated BLAST to search for 2.7.-.- or 2.7.7.39

Protein Sequence (156 amino acids)

>MMJJ_RS08780 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase (Methanococcus maripaludis JJ)
MIISNKDLLQDLIKDLRKNNLKIVFTNGCFDILHKGHVKYLSEAKKFGDILIVGINSDLS
IKKIKGSSRPVIPLESRIEVLNSIKPVDFVISFDEETPLNLISLIKPDVHVKGGDYTIES
LPESKIILEYGGKIKIINLVDGFSTTNIVSSILKGV