Protein Info for MMJJ_RS08720 in Methanococcus maripaludis JJ

Annotation: UDP-glucose/GDP-mannose dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03721: UDPG_MGDP_dh_N
  • amino acids 1 to 175 (175 residues), 204.5 bits, E=2.4e-64
• TIGR03026: nucleotide sugar dehydrogenase
  • amino acids 1 to 420 (420 residues), 414.9 bits, E=1.6e-128
• PF00984: UDPG_MGDP_dh
  • amino acids 196 to 288 (93 residues), 119.5 bits, E=1.1e-38
• PF03720: UDPG_MGDP_dh_C
  • amino acids 311 to 423 (113 residues), 78 bits, E=1.3e-25

Best Hits

KEGG orthology group: K00012, UDPglucose 6-dehydrogenase [EC: 1.1.1.22] (inferred from 77% identity to mvn:Mevan_0413)

Predicted SEED Role

"UDP-glucose 6-dehydrogenase (EC 1.1.1.22)" (EC 1.1.1.22)

MetaCyc Pathways

• UDP-α-D-glucuronate biosynthesis (from UDP-glucose) (1/1 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-α-D-xylose biosynthesis (1/2 steps found)
• colanic acid building blocks biosynthesis (6/11 steps found)
• UDP-sugars interconversion (2/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)

KEGG Metabolic Maps

• Ascorbate and aldarate metabolism
• Nucleotide sugars metabolism
• Pentose and glucuronate interconversions
• Starch and sucrose metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.22

Use Curated BLAST to search for 1.1.1.22

Protein Sequence (440 amino acids)

>MMJJ_RS08720 UDP-glucose/GDP-mannose dehydrogenase family protein (Methanococcus maripaludis JJ)
MKISVIGTGYVGLIQAVGLASFGFDVTGIDIDESKVKMLNNGVCPLYEDGLEKLLKKHVG
NNLKFTTSYEETIDSDVIFLCVGTPQDKEGNTDLKYIFSAVEMLKKHFQSQKWLVIKSTV
PIGTNRLLKERLTGYDIEIISNPEFLKEGVALKEFLNPERIVLGFDENDSSSKEILEKIY
KNFKEKNIPFILTNYETSEMIKYASNAFLATKISFINELSKLADKTNADIKTVAYSMGLD
DRIGKKFLNAGIGYGGSCFPKDVKSLIKQFEYNGVVPKIITATNSVNENQIKWFFGKIKN
YYGNINGKTFAILGLAFKPDTDDLRESAGIKLIDLLLCEGAIIKGYDYIKQARENACNIY
KSNASKPFHGSNFYVLDNLYDTVSNVDGIIITVEDNKLNYEDWSNIFNLASEKIIFDGKN
ILHKEKVEKFGFEYFGVGLK