Protein Info for MMJJ_RS08500 in Methanococcus maripaludis JJ

Annotation: L-sulfolactate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 64% identical to COMC_METJA: L-sulfolactate dehydrogenase (comC) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K05884, (R)-2-hydroxyacid dehydrogenase [EC: 1.1.1.272] (inferred from 95% identity to mmx:MmarC6_1534)

MetaCyc: 64% identical to L-2-hydroxycarboxylate dehydrogenase (Methanocaldococcus jannaschii)
R230-RXN [EC: 1.1.1.337]; 1.1.1.337 [EC: 1.1.1.337]

Predicted SEED Role

"L-sulfolactate dehydrogenase (EC 1.1.1.272)" (EC 1.1.1.272)

MetaCyc Pathways

(R)-cysteate degradation (2/3 steps found)
coenzyme M biosynthesis I (4/7 steps found)

KEGG Metabolic Maps

Cysteine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.272 or 1.1.1.337

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (347 amino acids)

>MMJJ_RS08500 L-sulfolactate dehydrogenase (Methanococcus maripaludis JJ)
MSHIITPEGEKKLLSDILMAYGVKKEHANITAEIYTEADLKGFTSHGIGRFPQTIIGLET
ENIKINPDIKIERESPATATINGDLALGYVTAAMAMDLAVEKAKNVGIGAVATYNSNHFG
ITGHYSERASKKGMIGIAITNTEPAMAPYGGKDKILGTNPIAIAISGKKHKYSLDMATAS
VARGKIFEAKRLGKTLPENAAVDVNGNITTDPDKALEGSILPFGGIKGYGIAMAVEILSA
IGGADIGTNVKGTARADEKCTKGDFFIAINPEFFGEKSEFLDKTDFLVDEIKNSRLSEGS
SEILIPGDVEARTSESKKNGFEIDEILYKKLKNICNKKGMIIENYLK